AOD-9604

AOD-9604 (CAS 221231-10-3) is a synthetic 16-residue peptide derived from the C-terminal region of human growth hormone (hGH). It is supplied for laboratory and analytical research use only.

Research background

AOD-9604 corresponds to hGH residues 177–191 with an added N-terminal tyrosine, and is also listed as Tyr-hGH Fragment 177-191. Because it reproduces only a short segment of the 191-residue parent protein, it has been used as a tool compound for studying that C-terminal region in isolation from the rest of the molecule.

Published preclinical work has examined AOD-9604 in rodent models of lipid metabolism, including studies of beta-3 adrenergic receptor expression in adipose tissue and comparisons with full-length hGH in wild-type and receptor-knockout mice (Heffernan et al., Endocrinology, 2001; Ng et al., Hormone Research, 2000). Other studies have looked at the fragment in a rabbit cartilage model (Kwon and Park, Annals of Clinical and Laboratory Science, 2015) and as a component of a nanoparticle delivery system in a breast cancer cell line (Habibullah et al., Drug Design, Development and Therapy, 2022). These findings are specific to the models and conditions used in each study. For a fuller summary of the literature and its limitations, see AOD-9604: A Research Overview of the hGH Fragment.

Specifications

• Compound: AOD-9604 (Tyr-hGH Fragment 177-191)
• CAS number: 221231-10-3
• Molecular formula: C₇₈H₁₂₃N₂₃O₂₃S₂
• Molecular weight: 1815.12 g/mol
• Appearance: Lyophilised white powder
• Purity: 99%+ verified by HPLC-MS
• Available sizes: 5mg, 10mg
• Presentation: Sealed, tamper-evident vial

Testing and verification

Every batch undergoes independent third-party HPLC-MS analysis confirming identity, quantity and purity. Each lot carries a unique batch identifier with its Certificate of Analysis published on our Lab Results page for full traceability.

Handling and storage

Supplied lyophilised. Store sealed vials cold and protected from light. Standard laboratory handling practices apply.

Research use only. This material is intended strictly for laboratory and analytical research. It is not a medicine, supplement or therapeutic good, and is not for human or veterinary consumption.

References

1. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. Endocrinology. 2001;142(12):5182–5189. PubMed 11713213
2. Ng FM, Sun J, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Hormone Research. 2000.
3. Kwon DR, Park GY. Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model. Annals of Clinical and Laboratory Science. 2015;45(4).
4. Habibullah MM, Mohan S, Syed NK, et al. Human growth hormone fragment 176-191 peptide enhances the toxicity of doxorubicin-loaded chitosan nanoparticles against MCF-7 breast cancer cells. Drug Design, Development and Therapy. 2022;16:1963–1974. doi:10.2147/DDDT.S367586

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