5-Amino-1MQ

5-Amino-1MQ is a research-grade inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular methylation balance and nicotinamide metabolism. NNMT activity has been associated with regulation of adipocyte energy balance, lipid storage, and insulin signaling, making it a target of interest in metabolic research.

By inhibiting NNMT, 5-Amino-1MQ is used to investigate NAD⁺-dependent energy pathways, including downstream effects on mitochondrial function and sirtuin signaling. Research models explore its role in fat mass regulation, insulin sensitivity, metabolic rate, and one-carbon metabolism, as well as the interaction between epigenetic regulation and metabolic function.