{"product_id":"mt-2-melanotan-ii","title":"MT-2 (Melanotan II)","description":"\u003cdiv class=\"wp-block-woocommerce-product-details alignwide is-style-minimal\" data-hide-tab-title=\"true\" data-block-name=\"woocommerce\/product-details\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"woocommerce-tabs wc-tabs-wrapper\"\u003e\n\u003cdiv aria-labelledby=\"tab-title-description\" role=\"tabpanel\" id=\"tab-description\" class=\"woocommerce-Tabs-panel woocommerce-Tabs-panel--description panel entry-content wc-tab\"\u003e\n\u003cp\u003eMelanotan II (MT-2) is a synthetic peptide analog of the naturally occurring hormone α-MSH (alpha-melanocyte-stimulating hormone). Research has explored MT-2 for its ability to bind to melanocortin receptors, which play a role in skin pigmentation and tanning responses. Studies have also investigated its potential influence on appetite and sexual function through these receptor pathways. MT-2 is commonly evaluated in laboratory settings for its possible applications in photoprotection, tanning, and metabolic research. It is intended strictly for scientific study and is not approved for human consumption or cosmetic use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"wp-block-woocommerce-product-collection alignwide is-layout-flow wp-block-woocommerce-product-collection-is-layout-flow\" data-tag-name=\"div\" data-query='{\"perPage\":3,\"pages\":1,\"offset\":0,\"postType\":\"product\",\"order\":\"asc\",\"orderBy\":\"title\",\"search\":\"\",\"exclude\":[],\"inherit\":false,\"taxQuery\":[],\"isProductCollectionBlock\":true,\"featured\":false,\"woocommerceOnSale\":false,\"woocommerceStockStatus\":[\"instock\"],\"woocommerceAttributes\":[],\"woocommerceHandPickedProducts\":[],\"filterable\":true,\"relatedBy\":{\"categories\":true,\"tags\":true}}' data-query-id=\"2\" data-query-context-includes='[\"collection\"]' data-hide-controls='[\"inherit\"]' data-display-layout='{\"type\":\"flex\",\"columns\":3,\"shrinkColumns\":false}' data-dimensions='{\"widthType\":\"fill\"}' data-collection=\"woocommerce\/product-collection\/related\" data-block-name=\"woocommerce\/product-collection\" data-__private-preview-state='{\"isPreview\":true,\"previewMessage\":\"Actual products will vary depending on the product being viewed.\"}' data-wp-router-region=\"wc-product-collection-2\" data-wp-interactive=\"woocommerce\/product-collection\" data-wp-init=\"callbacks.onRender\" data-wp-context='{\"notices\":[],\"hideNextPreviousButtons\":false,\"isDisabledPrevious\":true,\"isDisabledNext\":false,\"ariaLabelPrevious\":\"Previous products\",\"ariaLabelNext\":\"Next products\",\"collection\":\"woocommerce\\\/product-collection\\\/related\"}'\u003e\n\u003cdiv class=\"wc-block-components-notices alignwide\" data-wp-interactive=\"woocommerce\/store-notices\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cmeta charset=\"utf-8\"\u003eMelanotan II (MT-2) likely serves as a non-selective agonist with the potential to bind with four out of the five different subtypes of melanocortin receptors (MC-R).\u003csup dir=\"ltr\"\u003e(3)\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eDepending on the localization, the receptor-Melanotan 2 bond may induce different actions. Namely, the four receptors that Melanotan 2 may interact with include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe melanocortin 1 receptor (MC1R) may be expressed in melanocytes, which are cells found in tissues such as dermal tissues, hair, and possibly cells and tissues found in the eye.\u003c\/li\u003e\n\u003cli\u003eThe melanocortin 3 receptor (MC3R) might be found in a range of tissues, potentially including the brain and the placenta. Initial observations suggest that MC3R might be involved in modulating appetite under certain experimental conditions.\u003c\/li\u003e\n\u003cli\u003eThe melanocortin 4 receptor (MC4R) may be localized within the central nervous system, perhaps in the hypothalamus. Some early indications suggest that this receptor may impact neurons that are believed to have some influence over mating behaviors and general arousal.\u003c\/li\u003e\n\u003cli\u003eThe melanocortin 5 receptor (MC5R) appears to be distributed across multiple tissues, although what role it might serve remains unclear.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003eFor example, the potential interaction between Melanotan 2 and the MC1Rs may lead to increased production of eumelanin, which causes darkening of the epidermal layer’s pigment.\u003csup dir=\"ltr\"\u003e(4)\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eOn the other hand, when Melanotan 2 binds with the MC4R, it may induce supraspinal centers in the brain, which may lead to increased libido. These signals may then be carried to the sympathetic and parasympathetic centers in the spinal cord and thoracolumbar region.\u003csup dir=\"ltr\"\u003e(3)\u003c\/sup\u003e\u003c\/p\u003e\n\u003ch2\u003eChemical Makeup\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong dir=\"ltr\"\u003eOther Known Titles:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eMT-II\u003cbr dir=\"ltr\"\u003e\u003cstrong dir=\"ltr\"\u003eMolecular Weight:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e1024.19 g\/mol\u003cbr dir=\"ltr\"\u003e\u003cstrong dir=\"ltr\"\u003eMolecular Formula:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eC\u003csub dir=\"ltr\"\u003e50\u003c\/sub\u003eH\u003csub dir=\"ltr\"\u003e69\u003c\/sub\u003eN\u003csub dir=\"ltr\"\u003e15\u003c\/sub\u003eO\u003csub dir=\"ltr\"\u003e9\u003c\/sub\u003e\u003c\/p\u003e\n\u003ch2\u003eResearch and Clinical Studies\u003c\/h2\u003e\n\u003ch3\u003e\u003cem\u003eMelanotan 2 Peptide and Nerve Cell Regeneration\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003eResearch\u003csup dir=\"ltr\"\u003e(5)\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003ein a murine model of an induced peripheral nerve injury has been employed to investigate the neurotrophic potential of Melanotan 2. 48 hours after half of the murine models were presented with the peptide, it was noted that the Melanotan 2 research models appeared to indicate a recovery in their sensory function. Furthermore, when the murine models were presented with a chemotherapeutic compound, Melanotan 2 appeared to exhibit neuroprotective properties, which protected the nerves from the compound's induced neurotoxicity to a certain extent. This potential is posited to be mediated via the MC4 receptors, which might even promote neurite outgrowth and possibly support the intrinsic capacity of neuronal tissue to recover after injury.\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eAlthough the exact signaling pathways are not fully understood, it is often suggested that the pro-opiomelanocortin (POMC)-derived melanocortin peptides, including compounds analogous to a-melanocyte-stimulating hormone (a-MSH), may influence neuronal structures by increasing the number and length of neurites and potentially promoting nerve sprouting in damaged regions. Since Melanotan 2 is considered a potent melanocortin receptor agonist, it may trigger a cascade of intracellular events that theoretically lead to a better-supported ability of nerve fibers to regenerate after various forms of insult, as well as a partial protective response against toxic neuropathic conditions. Therefore, the researchers concluded that they “\u003cem dir=\"ltr\"\u003eobserved that Melanotan-II also possesses neuroprotective properties, as it partially protected the nerve from a toxic neuropathy induced by cisplatin.\u003c\/em\u003e”\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMelanotan 2 Peptide and Arousal Neurosignaling\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003eIn a clinical study,\u003csup dir=\"ltr\"\u003e(6)\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eMelanotan 2 has been suggested to induce increased arousal neuron signaling in more than 80% of cases, compared to only 20% success with a placebo. This research peptide may act via the MC4 receptors and downstream of established neuromodulators, including dopaminergic and oxytocinergic signals, possibly integrating their actions within discrete hypothalamic centers. These regions are thought to coordinate various homeostatic and motivational behaviors, and the introduction of an agonist like Melanotan 2 may potentially reframe the balance of neuronal activity. These researchers also posit that the involvement of MC5 receptors in certain peripheral glands may potentially provide a parallel route that links central neuro signaling with peripheral modulatory factors. However, this remains an area where mechanisms are only hypothesized.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMelanotan 2 Peptide and Neurodevelopmental Modulation\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003eResearchers have said that Melanotan 2 may potentially influence aberrant neural mechanisms by possibly stimulating populations of neurons that may govern social cognition through endogenous oxytocinergic signaling.\u003csup dir=\"ltr\"\u003e(7)\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eThese MC4R-sensitive circuits, potentially located in regions such as the paraventricular nucleus of the hypothalamus, might release endogenous oxytocin in response to Melanotan 2, possibly recalibrating imbalanced neurochemical activity thought to underlie key aspects of social impairment. This oxytocin release may, in turn, modulate neurotransmission involving serotonin, glutamate, dopamine, and GABA, all of which are implicated in shaping social adaptation.\u003c\/p\u003e\n\u003cp\u003eBy engaging these systems, Melanotan 2 may alter the functional connectivity of cortical and subcortical networks—regions including, for instance, the anterior cingulate cortex—where oxytocin receptor distribution may differ in atypical neurodevelopmental contexts. In doing so, researchers have been able to hypothesize that Melanotan 2 might restore or modify synaptic communication and synaptic plasticity, which may go so far as to reshape the underlying neuroarchitecture.\u003c\/p\u003e\n\u003ch3\u003e\u003cem\u003eMelanotan 2 Peptide and Models of Sunless Tanning\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003eMelanotan 2 may increase melanin production and thereby induce darker pigmentation without the need for ultraviolet irradiation by engaging the MC1R on melanocytes.\u003csup dir=\"ltr\"\u003e(8)\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eMoreover, the peptide's cyclic structure supports a more prolonged metabotropic activity compared to other MSH analogs.\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003eAlthough the precise intracellular signaling cascades remain incompletely understood, current data suggest that receptor interactions might lead to the elevated synthesis of eumelanin. This might offer a potential pathway for the development of sunless tanning models in a controlled research environment. Specifically, researchers have made comments about their observation of outcomes in research models, such as “\u003cem dir=\"ltr\"\u003eincreased [darkened] pigmentation in the face, upper body, and buttock\u003c\/em\u003e” in experimental settings.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong dir=\"ltr\"\u003eMelanotan 2 peptide is available for research and laboratory purposes only. \u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003ch3\u003eReferences:\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eRyakhovsky, Vladimir V et al. “The first preparative solution phase synthesis of Melanotan II.” Beilstein Journal of Organic Chemistry vol. 4 (2008): 39. doi:10.3762\/bjoc.4.39.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19043625\/\" rel=\"noopener\" dir=\"ltr\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/19043625\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMac E. Hadley, Discovery that a melanocortin regulates sexual functions in male and female humans, Peptides, Volume 26, Issue 10, 2005, Pages 1687-1689, ISSN 0196-9781,\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.peptides.2005.01.023\" rel=\"noopener\" dir=\"ltr\"\u003ehttps:\/\/doi.org\/10.1016\/j.peptides.2005.01.023\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKing, Stephen H et al. “Melanocortin receptors, melanotropic peptides and penile erection.” Current topics in medicinal chemistry vol. 7,11 (2007): 1098-1106.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2694735\/\" rel=\"noopener\" dir=\"ltr\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2694735\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePeters, Björn, et al. “Melanotan II: a possible cause of renal infarction: review of the literature and case report.” CEN case reports vol. 9,2 (2020): 159-161. doi:10.1007\/s13730-020-00447-z.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7148395\/\" dir=\"ltr\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7148395\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eTer Laak, Mariël P, et al. “The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.” European Journal of Pharmacology vol. 462,1-3 (2003): 179-83. doi:10.1016\/s0014-2999(02)02945-x.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12591111\" rel=\"noopener\" dir=\"ltr\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/12591111\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eWessells, H et al. “Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.” International journal of impotence research vol. 12 Suppl 4 (2000): S74-9. doi:10.1038\/sj.ijir.3900582.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11035391\/\" rel=\"noopener\" dir=\"ltr\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/11035391\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMinakova E, Lang J, Medel-Matus JS, Gould GG, Reynolds A, Shin D, Mazarati A, Sankar R. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS One. 2019 Jan 10;14(1):e0210389. Doi: 10.1371\/journal.pone.0210389. PMID: 30629642; PMCID: PMC6328175.\u003c\/li\u003e\n\u003cli\u003eDorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-84. doi: 10.1016\/0024-3205(96)00160-9. PMID: 8637402.\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"PureX Labs","offers":[{"title":"10mg","offer_id":47548289220852,"sku":null,"price":25.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0804\/5802\/3156\/files\/Render_Mockup_1920_1920_2026-01-31_3.png?v=1769802134","url":"https:\/\/purexlabs.io\/products\/mt-2-melanotan-ii","provider":"PureX Labs","version":"1.0","type":"link"}